Most living organisms, including humans, age. Over time the ability to do physical and intellectual work deteriorates, and susceptibility to infectious, metabolic, and neurodegenerative diseases increases, which leads to general fitness decline and ultimately to death. Work in model organisms has demonstrated that genetic and environmental manipulations can prevent numerous age-associated diseases, improve health at advanced age, and increase life span.
My laboratory uses a diverse range of techniques to study the process of aging. We use mouse models, cell culture, biochemistry, and computational methods to better understand normal and pathological processes that accompany human aging, and to develop interventions to delay aging and ameliorate age-related diseases such as cancer, metabolic syndrome, and neuro-degeneration.